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14532: ADAMTSs13 Activity with Reflex to Inhibitor Print View
ADAMTS13 Activity IA  68 - 163  % Activity 

PRIMARY
1 Plasma Citrated 1 (0.5) mL   Frozen - 21 Day(s)  
ALTERNATE

ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a lifethreatening hematological condition characterized by low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS-13 that inhibits enzyme activity.

Platelet Poor Plasma: Centrifuge light blue-top tube 15 minutes at
approx. 1500 g within 60 minutes of collection. Using a plastic
pipette, remove plasma, taking care to avoid the WBC/platelet buffy
layer and place into a plastic vial.
Centrifuge a second time and transfer platelet-poor plasma into a new
plastic vial. Plasma must be free of platelets (<10,000/mcl). Freeze
immediately and ship on dry ice.
Setup Schedule
Sunday-Thursday

Reported (Analytical Time)
Next day

CPT Code
85397

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: EDTA plasma Specimen Stability: Frozen -20 deg C: 21 days -70 deg C: 6 months Transport Temperature: Frozen If the ADAMTS13 Activity result is < or = 30%, ADAMTS13 Inhibitor will be performed at an additional charge. (CPT code: 85335).






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