Treatment of CMV diseases includes three licensed drugs: ganciclovir, foscarnet and cidofovir. All three drugs inhibit the viral DNA polymerase through various mechanisms. Over time, as CMV makes copies of itself, the virus can change its structure. These changes may make CMV resistant to the effects of antiviral drugs. Therefore, it is important to detect resistance as quickly and accurately as possible for proper management of CMV infection.
Plasma: Collect blood in sterile tubes containing EDTA
anticoagulant; either 0.15% solution v/v final EDTA K3
(standard EDTA tube) or 9 mg spray-dried EDTA K2 (Plasma
Preparation Tube or PPT tube with plasma separator-gel,
preferred). Store whole blood at room temperature and
separate plasma from cells preferably within 2 hours of
collection. Transfer plasma collected in standard EDTA
tubes to sterile, plastic, screw-capped, aliquot tubes and
store at -18 C or colder. If blood is collected in a PPT
tube, centrifuge preferably within 2 hours of collection,
but it is not necessary to transfer the plasma to aliquot
tubes. Following centrifugation, a gel barrier maintains
separation of plasma from cellular components during
specimen transport and storage, the PPT tube is plastic
and hence plasma can be stored and shipped frozen in the
original tube. Avoid repeated freezing and thawing of
specimen. Ship refrigerated (stable for 8 days) or frozen
(stable for 30 days).
Blood: Collect blood in sterile tubes containing EDTA as
an anticoagulant. Ship refrigerated (stable for 8 days) or
frozen (stable for 30 days).
CSF: Collect in a sterile container and ship frozen (CSF
is stable at room temperature for 1 day, refrigerated for
1 day, or frozen for 30 days).
BAL: Collect in a sterile container and ship refrigerated
(stable for 8 days) or frozen (stable for 30 days).
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
CPT coding is the sole responsibility of the billing party.
Please direct any questions regarding coding to the payer being billed.
**This test is not available for New York patient testing**
METHODOLOGY: PCR, DNA Sequencing
Reject Criteria: Samples containing heparin; Unspun PPT tube; Received room temperature