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14989: Microsatellite Instability (msi), [14989] Print View
MIS      

PRIMARY
1 Whole Blood EDTA 5 (2) mL   Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)  
2 Tissue Paraffin Block   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  
ALTERNATE
  Whole Blood ACD Sol B 5 (2) mL   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Whole Blood Heparin 5 (2) mL   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Tissue Para Block Bag   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  

Patients with early onset and family history of colon cancers are suggestive of Hereditary Nonpolyposis Colon Cancer (HNPCC) syndrome. Microsatellite instability analysis on tumor tissue is recommended as a screening test to identify individuals eligible for germline mutation analysis of mismatch repair genes. Microsatellite instability analysis can also be used to identify adult and pediatric patients with unrespectable or metastatic solid tumors who have failed frontline therapy and who would be candidates for targeted immune therapy with Keytruda (pembrolizumab).

One formalin-fixed paraffin embedded tissue with representative tumor
AND one EDTA whole blood from the same patient must be submitted for
testing. Both sample types are required for testing.
OR
One formalin-fixed paraffin embedded tissue with representative tumor
and one formalin-fixed paraffin embedded tissue with normal tissue.
Avoid hemolysis.
Setup Schedule
Wednesday, Saturday

Reported (Analytical Time)
3 days

CPT Code
81301

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Methodology: Polymerase Chain Reaction, Capillary Electrophoresis
Transport Temperature: Room Temperature.
Preferred Specimen:
5 mL whole blood collected in EDTA (lavender-top), Sodium heparin (green-top), or ACD solution (yellow-top) and Formalin fixed paraffin embedded tissue w/tumor collected in Formalin fixed, paraffin embedded tissue block or Paraffin Block Bag.
Other Acceptable Specimens:
Formalin fixed paraffin embedded tissue collected in Formalin fixed, paraffin embedded tissue block or Paraffin Block Bag and Formalin fixed paraffin embedded tissue with tumor collected in Formalin fixed, paraffin embedded tissue block or Paraffin Block Bag.






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