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16128: RAS Mutation Analysis, Cell-Based [16128] Print View
Sample Type      
Block ID      
HRAS Mutation Analysis   Negative   
KRAS Mutation Analysis   Negative   
NRAS Mutation Analysis   Negative   

PRIMARY
1 Whole Blood EDTA 5 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Tissue Paraffin Block   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  

Activating RAS mutations can be found in human malignancies with an overall frequency of 15-20%. A high incidence of RAS gene mutations has been reported in malignant tumors of the pancreas (80-90%, KRAS), in colorectal carcinomas (30-60%, KRAS), in non-melanoma skin cancer (30-50%, HRAS), in hematopoietic neoplasia of myeloid origin (18-30%, KRAS or NRAS).

Specimen Requirements: 5 mL (4.0 mL) peripheral blood collected in an
EDTA (lavender-top) tube
Alternate:
Paraffin embedded tissue (IHC specimen transport kit) or 3 mL (2.0 mL)
Bone marrow collected in an EDTA (lavender top) tube.


Submission of whole blood (preferred): Follow standard whole blood
collection procedure. Collect 3-5 mL whole blood samples in EDTA tube.
Blood samples are shipped at room temperature or 4 C. Do not freeze
whole blood. Record the draw time and date on the tube. Ship
immediately to maintain sample stability.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days


Notes
CPT CODES: 83898,83909,83904,83912,81404+RC,81275+RC METHODOLOGY: Polymerase Chain Reaction (PCR), Sequencing REJECTION CRITERIA: Gross hemolysis, Received frozen, Clotted






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