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16510: Kras Mutation Analysis [16510] Print View
Specimen Source      
Paraffin Block Number      
KRAS Mutation Analysis      

PRIMARY
1 Tissue Paraffin Block   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Whole Blood EDTA 6 (4) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  

Activating KRAS mutations can be found in human malignancies with an overall frequency of 15-20%, including 25-35% of lung adenocarcinomas, 60-90% of malignant tumors of the pancreas, 30-45% of colorectal carcinomas, and 18-30% of hematopoietic neoplasms of myeloid origin. KRAS proteins have been shown to influence proliferation, differentiation, transformation, and apoptosis by relaying mitogenic and growth signals into the cytoplasm and the nucleus. Mutations leading to an amino acid substitution at positions 12, 13, 61 and 146 are of KRAS are the most common in naturally occurring neoplasms. The presence of KRAS mutation in most tumor types is associated with adverse prognosis as well as resistance to receptor tyrosine kinase-directed targeted therapies, including against EGFR.

Submission of formalin-fixed, paraffin-embedded tissue is the
preferred sample type. Other sample
types listed are acceptable for testing. For submission of paraffin
block, another preferred specimen
type, tissue source and block ID are required on the requisition form.
A pathology report must be submitted.
Whole Blood: Follow standard whole blood collection procedures.
Collect 4-6 mLs whole blood in an EDTA
tube. Record sample type, collection time and date onto tube and
requisition form.
Bone Marrow collection, the notation of sample type, collection time
and date onto the tube and
requisition form is required. Ship sample at refrigerated temperature
or room temperature. Ship immediately to maintain stability.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Codes
81276,81275

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature
Methodology: Polymerase Chain Reaction; Sequencing
Specimen Stability: Formalin fixed paraffin embedded tissue, 5 years Room temperature and Refrigerated
Reject Criteria: Frozen specimens: Unacceptable






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