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16510: KRAS Mutation Analysis [16510] Print View
Specimen Source      
Paraffin Block Number      
KRAS Mutation Analysis      

PRIMARY
1 Tissue Paraffin Block   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Whole Blood EDTA 6 (4) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  

Activating KRAS mutations can be found in human malignancies with overall frequency of 15-20%. A high incidence of KRAS gene mutations has been reported in 25-35% of lung adenocarcinomas, 60-90% malignant tumors of the pancreas, 30-60% in colon rectal carcinomas, and in 18-30% of hematopoietic neoplasia of myeloid origin. KRAS proteins were shown to influence proliferation, differentiation, transformation, and apoptosis by relaying mitogenic and growth signals into the cytoplasm and the nucleus. Mutations leading to an amino acid substitution at positions 12, 13 and 61 are the most common in naturally occurring neoplasms.

Submission of formalin-fixed, paraffin-embedded tissue is the
preferred sample type. Other sample
types listed are acceptable for testing. For submission of paraffin
block, another preferred specimen
type, tissue source and block ID are required on the requisition form.
A pathology report must be submitted.
Whole Blood: Follow standard whole blood collection procedures.
Collect 4-6 mLs whole blood in an EDTA
tube. Record sample type, collection time and date onto tube and
requisition form.
Bone Marrow collection, the notation of sample type, collection time
and date onto the tube and
requisition form is required. Ship sample at refrigerated temperature
or room temperature. Ship immediately to maintain stability.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Codes
81276,81275

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature Methodology: Polymerase Chain Reaction; Sequencing

Specimen Stability:
Tissue block: Room temperature and Refrigerated: Indefinite Whole blood and bone marrow: Room temperature and Refrigerated: 72 hours All specimens: Do not freeze






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