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16539: JAK2 V617F Mutation, Ql w/Reflex to Exons 12 and 13 Leumetaź Print View
Sample Type:      
JAK2 V617F PCR     

PRIMARY
1 Whole Blood EDTA 6 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  

Myeloproliferative disorders (MPDs) are clonal hematopoietic stem cell malignancies characterized by excessive production of blood cells by hematopietic precursors. In addition to thrombotic and hemorrhagic complications, leukemic transformation can occur. The main members of MPD are Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Idiopathic Myelofibrosis (MF). The molecular pathogenesis of most MPDs is unknown. This V617F mutation leads to constituitive tyrosine phosphorylation activity that promotes cytokine activity and induces erythrocytosis. The V617F mutation in JAK2 is a dominant gain-of function mutation that contributes to the expansion of the myeloproliferative disorder clone. JAK2 exon 12 mutations define a distinctive myeloproliferative syndrome.

Submission of whole blood (preferred): Follow standard whole blood
collection procedure. Collect 3-5 mL whole blood samples in EDTA tube.
Blood samples are shipped at room temperature or 4 degrees C. Do not
freeze whole blood. Record the draw time and date on the tube. Ship
immediately to maintain sample stability.
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Transport Temperature: Refrigerated
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Reject Criteria: Frozen whole blood and bone marrow
Setup Schedule
Monday-Saturday

Reported (Analytical Time)
Next day

CPT Code
81270

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
CPT CODES: 83891, 83902, 83898, 83904, 83912






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