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16818: NRAS Mutation Analysis [16818] Print View
Specimen Source      
Paraffin Block Number      
NRAS Mutation Analysis      

PRIMARY
1 Tissue Paraffin Block   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  
ALTERNATE
  Whole Blood EDTA 3 (1) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
  Bone Marrow Aspirate   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  

N-RAS mutations have been described in 12% of leukemias, 18% of skin cancers, 18% of small intestine cancers, 3% of colon cancers, and 7% of thyroid cancer.

Specimen Requirements: Formalin fixed paraffin embedded tissue
or 6 mL (4.0 mL) whole blood collected in an EDTA (lavender-top) tube.

Alternate:
3 mL (1.0 mL) bone marrow aspirate collected in an EDTA (lavender-top)


Paraffin block is the preferred sample type. Sample source and block
ID are required on the requisition
form. A pathology report must be submitted.
Whole Blood: Follow standard whole blood collection procedures.
Collect 5-6 mLs whole blood in an EDTA
tube. Record sample type, collection time and date onto tube and
requisition form.
Bone marrow collection, the notation of sample type, collection time
and date onto the tube and
requisition form is required. Ship sample at refrigerated temperature
or room temperature. Ship
immediately to maintain stability.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Code
81311

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
CPT CODES: 81404+NR **The 2012 AMA CPT codebook contains Tier 1 and Tier 2 Molecular Pathology Procedures as well as Molecular Pathology Procedures to be coded by procedure rather than analyte. Please direct any questions regarding coding to the payor being billed. METHODOLOGY: Polymerase Chain Reaction, Sequencing REJECTION CRITERIA: Gross hemolysis, Clotted whole blood or bone marrow






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