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1762: Free Kappa & Lambda, w/ K/L Ratio, w/Rfx Immunofixation Serum Print View
Free Kappa, Serum IMMUNOTURB  3.3 - 19.4  mg/L 
Free Lambda, Serum IMMUNOTURB  5.7 - 26.3  mg/L 
Free Kappa/Lambda Ratio CALC  0.26 - 1.65   

PRIMARY
1 Serum 2 (1) mL   Frozen - 3 Month(s)/Refrigerated - 21 Day(s)/Room Temperature - 7 Day(s)  
ALTERNATE
  Serum Separator Tube 2 (1) mL   Frozen - 3 Month(s)/Refrigerated - 21 Day(s)/Room Temperature - 7 Day(s)  

This test is a latex-enhanced, immunoassay that provides ultrasensitive detection and quantitation of free light chains (FLCs) in serum or urine earlier than electrophoresis. It is an aid in the diagnosis and treatment of multiple myeloma, lymphocytic neoplasms, Waldenstroms macroglobulinemia and connective tissue diseases, such as systemic lupus erythematosus. Approximately 15% of all cases of multiple myeloma produce only free kappa or lambda light chains in excess. These patients frequently show no abnormality on serum protein electrophoresis. Quite often urine is tested for the presence of these light chains, which are also called Bence Jones Proteins. However, the FLCs entering the urine are strongly influenced by renal tubular function. When clonal proliferation of plasma cells starts to develop, the FLC concentration increases in serum. Since these small particles are rapidly cleared by the renal tubules, urine tests for FLCs remain negative until the tumor mass expands, and the FLCs in serum exceed the resorptive capacity of the renal tubules. Therefore, the the measurement of FLCs in serum is an alternative to less sensitive urine testing. Changing concentrations of FLCs in serum relate better to changing tumor load than to concentrations in urine.

Microbially contaminated serum samples containing particulate matter
and lipemic or hemolyzed serum samples should be rejected.
Transport Temperature: Refrigerated
Setup Schedule
Monday-Friday

Reported (Analytical Time)
Same day

CPT Code
83883x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature Reject Criteria: Gross hemolysis; Grossly lipemic; Microbially contaminated serum; Specimens containing heavy visible particulate. If Kappa/Lambda Ratio is <0.8 or >1.9, Immunofixation will be performed for an additional fee (add CPT code 86334).






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