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19548: Metanephrines, Fractionated, Free, Lc/ms/ms, Plasma Print View
Metanephrine, Free     pg/mL 
Normetanephrine, Free     pg/mL 
Total, Free (MN + NMN)     pg/mL 

PRIMARY
1 Plasma EDTA 2.5 (1.5) mL   Frozen - 14 Day(s)/Refrigerated - 14 Day(s)/Room Temperature - 4 Hour(s)  
ALTERNATE

Normetanephrine (NM) and metanephrine (MN) are the extra-neuronal catechol-o-methyl transferase (COMT) metabolites of the catecholamines norepinephrine and epinephrine, respectively. Measurement of plasma metanephrines is more sensitive (but may be less specific) than measurement of catecholamines for the detection of heochromocytoma. Proper interpretation of results requires awareness of recent medication/drug history (e.g., antyhypertensive agents, alcohol, cocaine) and other pre-analytical factors (e.g., stress, severe congestive heart failure, myocardial infarction) that influence release of catecholamines and metanephrines.

Patient Preparation: Patient should avoid alcohol, coffee, tea,
tobacco and strenuous exercise prior to collection. Overnight fasting
is preferred. Patients should be relaxed in either a supine or
upright position before blood is drawn.

Draw specimen in a pre-chilled EDTA laveder-top Vacutainer (TM).
The whole blood sample should be kept on wet ice until centrifuge
(preferably at 4 degrees C) to separate the plasma within 2 hours of
venipuncture. After centrifugation, the plasma should be transferred
to a plastic, leak-proof vial and immediately refrigerated.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Code
83835

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Heparinized plasma; Serum; CSF; Urine Methodology: Liquid Chromatography/Tandem Mass Spectrometry






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