Immunofixation of urine is useful in evaluation of monoclonal free light chains and other monoclonal gammopathies seen in light chain disease, multiple myeloma, Waldenstrom's macroglobulinemia, amyloidosis, and other lymphoproliferative disorders. Increased polyclonal free light chains in urine may be seen in glomerular leak syndromes and in infection or inflammation.
Reported (Analytical Time)
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Preferred Specimen: 50m mL (10 mL minimum) random urine, no preservative or 24-hour urine, no preservative collected in a plastic screw-cap container or Urinalysis transport tube (yellow-top, blue fill line, preservative tube). Transport Temperature: Room temperature Methodology: Immunofixation