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22: Activated Protein C Resistance [22] Print View
APC Resistance     ratio 

PRIMARY
1 Plasma Citrated 2 (1) mL   Frozen - 60 Day(s)  
ALTERNATE

Activated protein C (APC) resistance is the most frequent hereditary defect associated with deep vein thrombosis. Over 95% of the APC resistance phenotype is due to the Factor V Leiden mutation. The APC- Resistance assay is a plasma based functional test for the determination of APC resistance caused by the factor V Leiden mutation.

Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes
at approx. 1500 x g within 60 minutes of collection. Using a plastic
pipette, remove plasma, taking care to avoid the WBC/platelet
buffy layer and place into a plastic vial. Centrifuge a second
time and transfer platelet-poor plasma into a new plastic vial.
Plasma must be free of platelets (<10,000/mcl). Freeze immediately
and ship on dry ice.

Reject Criteria:
Received room temperature; received refrigerated; clotted specimen;
serum; gross hemolysis
Setup Schedule
Thursday

Reported (Analytical Time)
Same day

CPT Code
85307

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Specimen Stability
Room temperature and Refrigerated: Unacceptable
Frozen: 60 days
Transport Temperature: Frozen
Methodology: RVVT-based Assay (Clot-based)
Reject Criteria: Received room temperature; received refrigerated; clotted specimen; serum; gross hemolysis






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