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35799: Kras And Nras Mutation Analysis, Cell-based Print View
Sample Type:      
Block ID:      
KRAS Mutation, Cell-based      
NRAS Mutation, Cell-based      

PRIMARY
1 Tissue Paraffin Block   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE
  Bone Marrow EDTA   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
  Whole Blood EDTA 6 (4) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  

Recent studies have shown that mutations in KRAS and NRAS exons 2, 3, and 4 have influence on response to anti-EGFR therapy. Testing these genes will aid in selection of patients who will likely respond to anti-EGFR therapy.

Submission of formalin-fixed, paraffin-embedded tissue is the
preferred sample type. Other sample types listed are acceptable
for testing. For submission of paraffin block, another preferred
specimen type, tissue source and block ID are required on the
requisition form.

A pathology report must be submitted.

Whole Blood: Follow standard whole blood collection procedures.
Collect 4-6 mLs whole blood in an EDTA tube. Record sample
type, collection time and date onto tube and requisition form.

Bone Marrow collection, the notation of sample type, collection
time and date onto the tube and requisition form is required.
Ship sample at refrigerated temperature or room temperature.
Ship immediately to maintain stability.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
3 days

CPT Codes
81311,81276,81275

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Specimen Requirements:
Preferred: Formalin fixed paraffin embedded tissue
Acceptable: 6 mL (4 mL minimum) whole blood or 3 mL (1 mL minimum) bone marrow submitted in an EDTA (lavender-top) tube
Specimen Stability: Formalin fixed paraffin embedded tissue, 5 years Room temperature and Refrigerated
Transport Temperature: Room temperature
Reject Criteria: Frozen specimens: Unacceptable
Methodology: Polymerase Chain Reaction, Sequencing






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