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36178: Insulin Autoantibody Print View
Insulin Autoantibody RBA  < .4  U/mL 

PRIMARY
1 Serum 1 (0.2) mL   Room Temperature - 28 Day(s)/Refrigerated - 28 Day(s)/Frozen - 28 Day(s)  
ALTERNATE

Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Insulin Antibody is useful in assessing lower titers of autoantibody in patients with diabetes, detecting insulin autoantibody in patients who are "prediabetic," and in detecting autoantibody in patients with other autoimmune disorders. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type I diabetes. There is a correllation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
Setup Schedule
Sunday, Tuesday, Thursday

Reported (Analytical Time)
Next day

CPT Code
86337

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Limitations: In diabetic children <14 years of age (identified by urine screening), the frequency of insulin antibodies (IAA) and islet cell antibodies (ICA) are 43-56% and 84%, respectively; the frequency of both is 40%, and the frequency of one or both is 88%.4. In the same study, cohorts using ICA, GAD-65 antibodies and IAA, sensitivities and specificities are 93% and 93% for any positive, respectively, and 39% and >99%, respectively, for all positives. IAA are found at onset of diabetes in only 4% of adults, but are universally present in diabetic children <4 years old at onset. The predictive value of both tests (ICA and IAA) is 60-77% in first-degree relatives of patients with IDDM for the development of IDDM in 5-10 years.






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