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36509: Cardio Iq(r) Insulin Resistance Panel With Score Print View
Insulin, Intact, LC/MS/MS     uIU/mL 
C-peptide, LC/MS/MS     ng/mL 
Insulin Resistance Score      

PRIMARY
1 Serum 0.5 (0.3) mL   Room Temperature - 24 Hour(s)/Refrigerated - 28 Day(s)/Frozen - 28 Day(s)  
ALTERNATE

The determination of insulin in serum is primarily used for the diagnosis of glycemic disorders in diabetic and pre-diabetic patients in the assessment of insulin resistant syndromes. Insulin is synthesized by the pancreatic beta cell as a precursor, proinsulin. Proinsulin is processed to insulin and C-peptide, a contiguous peptide between the insulin A and B chains, as it passes through the cell. The C-peptide in the proinsulin ensures correct folding and processing of proinsulin as it passes through the cell. Both insulin and C-peptide are released together from the beta cells in response to increased glucose levels. Because of differences in half-life and hepatic clearance, peripheral blood levels of C-peptide and insulin are no longer equimolar but remain highly correlated. A steady-state plasma glucose test in individuals undergoing an insulin suppression test to assess insulin resistance found that the combination of insulin and C-peptide was a better indicator of insulin resistance than either one individually.

Collect blood samples observing routine precautions for venipucture.
Allow serum samples to clot completely before centrifugation.

Patient Preparation: Overnight fasting is required.
Setup Schedule
Tuesday, Friday

Reported (Analytical Time)
3 days

CPT Codes
83525,84681

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Hemolysis
Transport Temperature: Refrigerated
Methodology: Immunocapture, Liquid Chromatography/Tandem Mass Spectrometry






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