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37358: Cryoglobulin Screen With Reflex To Cryoglobulin Panel Print View
Cryoglobulin, QL      

PRIMARY
1 Serum Red Top 10 (3.5) mL   Room Temperature - 72 Hour(s)  
ALTERNATE

Cryoglobulins are proteins that precipitate from serum at temperatures below 37 degrees C. Most precipitate when serum is cooled at 4 degrees C, but some gel even at room temperature. The gel or precipitate must redissolve at 37 degrees C to be classified as a cryoglobulin.

Collect 20 mL of fasting whole blood specimen in a red-top tube
(no gel). 10 mL serum required: 3.5 mL minimum. Avoid hemolysis.
Allow serum sample to clot for one (1) hour in a 37 degrees C water
bath, oven, incubator, or heat block. After clotting, centrifuge the
specimen for 10 minutes at 3000 rpm utilizing one of the 3 options
below:

1. In a "warm" centrifuge at 37 degrees C; or
2. In a bench-top centrifuge placed in a "warm room" at 37 degrees
C; or
3. At room temperature, in a bench-top centrifuge prewarmed by
running it for 10 minutes at 2000 rpm.
After centrifuging, decant serum into a screw-capped vial.
Transport at room temperature.
Note: No other tests can be added to the tube; cryocrit and
cryoglobulin evaluation only

Patient Preparation: Overnight fasting is required

Reject Criteria: Gross hemolysis; lipemia; icteric; serum separator
tube
Setup Schedule
Sunday-Friday

Reported (Analytical Time)
5 days

CPT Code
82595

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reflex Criteria: If cryoglobulin is present (positive), it is identified. Positives are semi-quantitated (as % cryoglobulin) by cryocrit. When Cryoglobulin Screen is positive, Cryoglobulin Profile (Cryocrit Immunofixation, Cryocrit Immunodiffusion and Rheumatoid Factor) will be preformed at an additional charge (CPT Codes(s):
86334, 86329, 86431).
Transport Temperature: Room Temperature
Methodology: Cryocrit, Immunodiffusion, Electrophoresis, Immunofixation (if needed), Rate Nephelometry






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