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37735: Acylglycines, Quantitative Panel, Urine Print View
Interpretation      
Ethylmalonic Acid     mg/g creat 
Methylsuccinic Acid     mg/g creat 
Propionylglycine     mg/g creat 
Isobutyrylglycine     mg/g creat 
Glutaric Acid     mg/g creat 
Butyrylglycine     mg/g creat 
2-Methylbutyrylglycine     mg/g creat 
Isovalerylglycine     mg/g creat 
3-Methylcrotonylglycine     mg/g creat 
Tiglylglycine     mg/g creat 
Hexanoylglycine     mg/g creat 
Phenylpropionylglycine     mg/g creat 
Trans-cinnamoylglycine     mg/g creat 
Suberylglycine     mg/g creat 
Creatinine, Random Urine     mmol/mol cr. 

PRIMARY
1 Urine 24 hour 10 (2) mL   Refrigerated - 72 Hour(s)/Frozen - 28 Day(s)  
2 Urine 10 (0.5) mL   Refrigerated - 72 Hour(s)/Frozen - 28 Day(s)  
ALTERNATE

Acylglycines are an important class of metabolites that are used in the diagnosis of several organic acidurias and mitochondrial fatty acid oxidation disorders. This test is intended for the diagnosis and monitoring of several organic acidemias and fatty acid disorders affecting multiple metabolic pathways. Disorders diagnosed by Acylglycines assay: Isovaleric acidemia 3-Methylcrotonyl-Co-A-carboxylase deficiency Short-chain acyl-CoA dehydrogenase(SCAD) deficiency Ethylmalonic Encephalopathy Propionic acidemia Glutaric aciduria type-1, 2 and 3 Medium-chain acyl-CoA dehydrogenase(MCAD) Beta-ketothiolase deficiency 17-Beta-hydroxysteroid dehydrogenase deficiency Isobutyryl-CoA dehydrogenase deficiency Short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) The test will also allow physicians to determine dietary compliance or the effectiveness of dietary/cofactor therapy for their patients. It can also be used, alone or in conjunction with other tests, to confirm the findings of a positive expanded newborn screen.

Sterile screw cap container. Ship frozen. Do not thaw.
From one thoroughly mixed sterile collection container, divide
into two sterile collections: (1) minimum 2 mL in sterile screw
cap container AND (2) minimum 0.5 mL in sterile screw cap
container. Freeze immediately. Send both samples together.
Patient age should be included.
Setup Schedule
Monday-Saturday

Reported (Analytical Time)
4 days

CPT Codes
82542,82570

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Specimen Reqiurements:
10 mL (2 mL minimum) urine collected in sterile cap container, with no preservative AND 10 mL (0.5 minimum) urine collected in sterile screw cap container.
Acceptable Specimen:
24 Hour Urine Catherized urine First void clean catch urine, no preservative
Reject Criteria:
Do Not THAW; Shipping Room Temp or refrigerated for more than 3 days; Samples with pH less than 2
Specimen Stability: Room temperature; Unacceptable
Transport Temperature: Frozen
Methodology: Gas Chromatography/Mass Spectrometry






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