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37742: Thiopurine S-Methyltransferase (TPMT) Genotype Print View
TPMT Genotype      
Ethnicity      
Clinical Indication      
Referring Physician      
Physician's Phone Number      

PRIMARY
1 Whole Blood EDTA 5 (3) mL   Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)  
ALTERNATE
  Whole Blood ACD Sol B 5 (3) mL   Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)  
  WB EDTA Trace Metal   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Sodium Heparin   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Whole Blood ACD Sol A 5 (3) mL   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Whole Bld Heparin Lithium   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  

Thiopurine S-methyltranferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase) catalyzes thiopurine S-methylation, an important metabolic pathway for antineoplastic and immunosuppressive drugs. In the US, 11% of the population show intermediate TPMT activity, and approximately 1 in 300 have TPMT deficiency. Given potentially fatal nature of hematopoietic toxicity when full doses of mercaptopurine or azathioprine are given to TPMT deficient patients, and the difficulty to measure TPMT accurately when patients have been given red cell transfusions, the molecular method to determine TPMT genotype permits prospective identification of patients at risk.

Whole blood: Normal phlebotomy procedure. Specimen stability is
crucial. Store and ship ambient immediately. Do not freeze.
Setup Schedule
Wednesday, Friday

Reported (Analytical Time)
5 days

CPT Code
81401

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature METHODOLOGY: Real-Time Polymerase Chain Reaction LIMITATIONS: This test detects 95% of the mutations in the TPMT gene and thus not all intermediate or slow metabolizers will be identified. *The 2012 AMA CPT codebook contains Tier 1 and Tier 2 Molecular Pathology Procedures as well as Molecular Pathology Procedures to be coded by procedure rather than analyte. Please direct any questions regarding coding to the payor being billed.






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