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37989: 14-3-3 Protein, CSF (Prion Disease) Print View
Est Prob Prion Dis in Patient     % 
RT-QuIC (CSF)*      
T-tau protein (CSF)++     pg/mL 
14-3-3 protein (CSF)++      

1 CSF 5 (2) mL   Frozen - 12 Month(s)/Room Temperature - 24 Hour(s)/Refrigerated - 14 Day(s)  

In CSF: Search for the presence of the 14-3-3 protein. The 14-3-3 protein is a marker for some prion diseases, such as Creutzfeldt-Jakob disease (CJD), when a number of other neurodegenerative conditions are excluded.

Patient Preparation: Required patient information:
Please complete and send the National Prion Requisition "Test Request
Form", available on the website at National Prion Disease Pathology
Surveillance Center with the sample.

In addition to our Test Request Form, all senders of CSF will be
required to also complete and submit our CSF Billing Requisition Form
only if the NPDPSC is to bill patient directly.

Instructions: Collect CSF by lumbar puncture. Discard first 2 mL that
flows from tap. Collect next 5 mL CSF, avoiding bloody tap.

Freeze within 20 minutes of collection. Store and transport frozen.
Ship using a styrofoam container with sufficient dry ice (5 lbs/24
hours). The NPDPSC requests a urine sample for research purposes with
all CSF samples if available. Ship Monday through Wednesday.

**Please note: Patient is also asked to submit a frozen urine sampl
(100-200 mL) for validation of a recently published diagnostic test
on Creutzfeldt-Jakob disease; no report will be issued. Please inform
patient and/or family that urine is used for research on a diagnostic
test and obtain oral consent.
Urine: ship double boxed using a styrofoam container with sufficient
dry ice (5 lbs/24 hours).
Setup Schedule
Tuesday, Thursday

Reported (Analytical Time)
9-12 days

**This test is not available for California, Pennsylvania, and Rhode Island patient testing. Please use test code 11194 - 14-3-3 Protein, CSF (Mayo P1433) for California, Pennsylvania and Rhode Island patient testing.**
Transport Temperature: Frozen
Frozen Stability: Indefinite
Methodology: Immunoassay, Real-Time Quaking-Induced Conversion (RT-QuIC)

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