Therapeutic drug monitoring for effective therapy. Risperidone is rapidly converted into its hydroxy metabolite in the liver. Peak concentration of risperidone occurs in about 1 hour following oral administration and for 9-hydroxyrisperidone the peak level is reached at 3 hours (17 hours for poor metabolizers). The elimination half-life of risperidone is 3 hours (20 hours for poor metabolizers), and is 21 hours for hydroxyrisperidone (30 hours for poor metabolizers).
Tuesday, Thursday, Saturday
Reported (Analytical Time)
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Risperidone and OH-Risperidone are approximately equally effective; therefore, the sum of their concentrations is reported as total active drug.
Transport Temperature: Room temperature
Reject Criteria: Serum separator tubes are not acceptable