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4144: Phenytoin, Free & Total Print View
Phenytoin Total IA  10 - 20  mg/L 
Phenytoin, Free UF-IA  1 - 2  mg/L 
Phenytoin Bound CALC    mg/L 

PRIMARY
1 Serum 2.5 (1.5) mL   Room Temperature - 4 Day(s)/Frozen - 30 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE

Phenytoin is an anticonvulsant drug, used for the treatment of epilepsy, particularly grand mal epilepsy, cortical focal seizures and temporal lobe epilepsy. Effective dosage is essential in regulating the effects of seizures. Toxicity of phenytoin usually affects the central nervous system. It is essential that phenytoin levels be monitored to adjust dosage requirements in achieving optimal therapeutic effects while avoiding both subtherapeutic and toxic drug levels. The unbound (free) drug is the pharmacologically active component of phenytoin. The percent free is influenced by renal disease, pregnancy, protein abnormalities, and other medical conditions.

Collect as a trough just before next dose. For patients receiving
fosphenytoin therapy, collect as a trough at least 2 hours after IV
infusion or at least 4 hours after intramuscular (IM) injection.
Serum separator tubes are not acceptable.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
Same day

CPT Codes
80185,80186

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Phenytoin, Free: Toxic levels are equal or greater than 3.0 mg/L. For Phenytoin Free only, use test code #4143. Reject Criteria Plasma






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