von Willebrand Disease is the most common hereditary bleeding disorder; it may also be acquired. von Willebrand Factor is necessary for platelet adhesion to injured endothelium. von Willebrand Factor Antigen, Multimeric Analysis is useful when type 2 Disease is suspected and to further categorize disease. For example, in type 2A, the loss of high molecular weight multimers is due to defective assembly and secretion or increased proteolysis.
Note: Storage of whole blood at refrigerated temperatures prior
to processing may lead to cryoprecipitate formation and falsely
low Factor VIII and von Willebrand Factor studies.
Platelet Poor Plasma: Centrifuge light blue-top tube 15 minutes
at approx. 1500 g within 60 minutes of collection. Using a plastic
pipette, remove plasma, taking care to avoid the WBC/platelet buffy
layer and place into a plastic vial. Centrifuge a second time and
transfer platelet-poor plasma into a new plastic vial. Plasma must be
free of platelets (<10,000/mcl). Freeze immediately and ship on dry
-70 degrees: 6 months
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
CPT coding is the sole responsibility of the billing party.
Please direct any questions regarding coding to the payer being billed.
Transport Temperature: Frozen Reject Criteria: Thawed plasma received room temperature or refrigerated; hemolysis Assay Category: LDT