Elevated GGT is found in all forms of liver disease. Measurement of GGT activity is used in diagnosis and treatment of alcoholic cirrhosis, as well as primary and secondary liver tumors. It is more sensitive than alkaline phosphatase, the transaminases, and leucine aminopeptidase in detecting obstructive jaundice, cholangitis, and cholecystitis. GGT levels rise earlier in liver disease and to higher levels than either leucine aminopeptidase or 5-nucleotidase levels. Moderate elevations are seen in infectious hepatitis. Elevated GGT levels have also been noted in chronic alcoholism, diabetes, and certain neurological disorders. Normal levels of GGT are seen in skeletal diseases; thus GGT in serum can be used to ascertain wheter a disease is skeletal or hepatobiliary.
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Reported (Analytical Time)
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