Increased IgA is associated with monoclonal IgA myeloma, respiratory and gastrointestinal infections, and malabsorption; decreased IgA is found in selective IgA deficiency and in ataxia telangiectasia.
Reported (Analytical Time)
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Transport Temperature: Refrigerated
Reject criteria: Grossly lipemic
Evaluate humoral immunity; monitor therapy in IgA myeloma. Selective IgA deficiency has an increased association with allergies, recurrent sinopulmonary infection, autoimmune disease, and the HLA A28, B14 or A1, B14 types. IgA deficiency accompanied by a deficiency of subclass IgG2 is associated with recurrent sinopulmonary infections. IgA gammopathies are found 24% of all the gammopathies. It is reduced in Hereditary Agammoglibulinemia (Bruton's disease), Hereditary Thymic Aplasia (DiGeorge Syndrome), Primary Acquired Dysgammaglobulinemias type I, II, and III. It is absent in Hereditary Ataxia Telangiectasia and elevated in Wiskott-Aldrich Syndrome.