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5921: LDL (Low Density Lipoprotein) Subfractions Print View
LDL 1 EP  < 58  mg/dL 
LDL 2 EP  < 31  mg/dL 
LDL 3 EP  < 7  mg/dL 
LDL 4 EP  < 1  mg/dL 
LDL 5 EP  < 1  mg/dL 
LDL 6 EP  < 1  mg/dL 
LDL 7 EP  < 1  mg/dL 
Cholesterol, Total S  < 20 years: 125 - 170
>= 20 years: 125 - 200 
mg/dL 
Calculated LDL CALC  < 130  mg/dL 
Mean LDL Particle Size CALC  > 26.7  nm 

PRIMARY
1 Serum Fasting 12 hr 2 (1) mL   Refrigerated - 7 Day(s) Split into two 1mL aliquots before shipping./// 
ALTERNATE

The measurement of LDL subfractions can be used to identify individuals at increased risk for coronary artery disease (CAD) and atherosclerosis. Small dense LDL particles (Non-type A) are more atherogenic than large LDL particles. The density of LDL particles is related to the triglyceride content, and may be more readily oxidized, or could be a marker for delayed clearance of atherogenic remnant particles. Non-Type A profiles may be found in individuals with borderline or elevated total cholesterol levels. The prevalence of Non-Type A increases with age, Type 2 diabetes, obesity, and post menopause. LDL particle size is valuable in predicting patient response to specific therapies to reduce CAD progression.

Patient preparation:

The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine
(NAC), when administered in therapeutic concentrations (for the
treatment of acetaminophen overdose), has been...determined to
interfere with assays for...Cholesterol, Uric Acid" where "NAC
interference may lead to falsely low results." According to
Beckman Coulter, the NAC interference should be insignificant by
12 hours after completion of the initial loading dose of an IV
infusion treatment regimen consisting of an initial loading dose
of 150 mg/kg administered over 1 hr, a second dose of 50 mg/kg
administered over 4 hrs and a third dose of 100 mg/kg administered
over 16 hrs.
Setup Schedule
Tuesday, Friday

Reported (Analytical Time)
Same day

CPT Codes
82465, 83701

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Frozen specimens are unacceptable. Please include fasting status on requisition.






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