Lupus Anticoagulants (LA) are members of a family of antibodies with phospholipid-protein specificity. LA may be defined as an immunoglobulin, IgG or IgM or a mixture of both, that interferes with one or more of the in-vitro phospholipid (PL) dependent tests of coagulation. These antibodies are not associated with a hemorrhagic diathesis, but rather have been linked to thrombotic events. In addition to thrombosis other clinical complications have been associated with the presence of LA. These include strokes, nonbacterial thrombotic endocarditis, livedo reticularis and a variety of of obstetrical complications such as intrauterine fetal death, recurrent spontaneous abortion, fetal growth retardation, early onset preeclampsia and chorea gravidarum.
Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes at
approx. 1500 g within 60 minutes of collection. Using a plastic
pipette, remove plasma, taking care to avoid the WBC/platelet buffy
layer and place into a plastic vial. Centrifuge a second time and
transfer platelet-poor plasma into a new plastic vial. Plasma must be
free of platelets (<10,000/mcL).
Freeze immediately and ship on dry ice.
Reject Criteria: Hemolysis, received thawed
Transport Temperature: Frozen
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
CPT coding is the sole responsibility of the billing party.
Please direct any questions regarding coding to the payer being billed.
Specimen Requirements: 3 mL (2 mL minimum) frozen platelet-poor plasma collected in a sodium citrate (light blue-top) tube Methodology: Clot Detection If PTT-LA is prolonged (>40 seconds), the Hexagonal Phase Confirm will be performed at an additional charge.(CPT:85598) If the Hexagonal Phase Confirm is positive or weakly positive a Thrombin Clotting Time will be performed at an additional charge. (CPT:85670) If dRVVT screen is prolonged (>45 seconds), the dRVVT Confirm will be performed at an additional charge.(CPT:85597) If dRVVT Confirm is positive, a dRVVT 1:1 Mix will be performed at an additional charge.(CPT:85613)