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90123: Chronic Urticaria Panel 2 (Comprehensive) Print View
Histamine Release   < 16  % 
Thyroid Peroxidase Ab   < 9  IU/mL 
Thyroglobulin Antibodies   < 2  IU/mL 
TSH, 3rd Generation     mIU/L 
IgE Ab (Anti-IgE IgG)   < 168  ng/mL 

1 Serum 1.5 (1) mL   Frozen - 28 Day(s)/Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  

Patients with a chronic form of urticaria who are positive with the functional Histamine Release (Chronic Urticaria) test have an autoimmune basis for their disease. A positive result does not indicate which autoantibody (anti-IgE or anti-Fc epsilon RI alpha chain) is present. A positive anti-IgE antibody does not exclude the presence of anti-Fc epsilon RI alpha chain antibody. Autoimmune thyroid disease coexists in approximately 25% of autoimmune chronic urticaria patients.

4.9 mL red-top (no gel) serum

Serum should be separated from the cells as asoon as possible after
visible clot formation (usually 15-30 minutes after collection).

Overnight fasting is preferred.

Patients taking calcinuerin inhibitors should stop their medication
for 72 hours prior to draw.

Reject Criteria: Gross hemolysis; Lipemic specimen; Icteric specimen;
SST(R) tubes; Sample other than serum; Heavy visible particulate
matter; Moderate hemolysis

Transport Temperature: Ship room temperature

Patient Prepartation:
Specimen collection after fluorescein dye angiography should be
delayed for at least 3 days. For patients on hemodialysis, specimen
collection should be delayed for 2 weeks. According to the assay
manufacturer Siemens: "Samples containing fluorescein can produce
falsely depressed values when tested with the ADVIA Centaur TSH3
Ultra assay."
Setup Schedule
Tuesday, Thursday

Reported (Analytical Time)
Next day

CPT Codes

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Includes: Histamine Release (Chronic Urticaria) *Thyroid Peroxidase Antibody (Anti-TPO) *Thyroglobulin Antibody* TSH, 3rd Generation *IgE Antibody (Anti-IgE IgG)

METHODOLOGY: Immunochemiluminometric Assay, Cell Culture and Immunoassay

According to the assay manufacturer Siemens:
"In general, the fluorescein clearance (requires) about 48 to 72 hours." For patients in "end stage renal disease on hemodialysis, the elimination will be delayed likely by several cycles of hemodialysis. Assuming the dialysis cycle serves as one half-life (and) using the rule of thumb that 5 half-lives are required to completely eliminate a compound, two weeks is conservative (if) dialysis is performed 3 times per week.

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