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90362: B-cell Receptor IGH Gene Rearrangement, PCR Print View
Clinical Indication:      
Specimen Source:      
Block/Specimen ID:      
IGH Result      
Pathologist Interpretation      

PRIMARY
1 Whole Blood EDTA 5 (3) mL   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Tissue Paraffin Block   Room Temperature - 12 Month(s)  
  Needle washings   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)  
  Tissue   Frozen - 12 Month(s)  
  Slides (12-Unstained)   Room Temperature - 12 Month(s)  

This assay, which interrogates the immunoglobulin heavy chain gene (IGH) by a PCR method based on the BIOMED-2 consensus, is useful for establishing clonality of B-cell lymphoid neoplasms and in the identification of minimal residual disease or early recurrence in patients with a previous diagnosis of a B-cell neoplasm. It can be used in association with immunoglobulin kappa light chain (IGK test code 90363, or IGH/IGK combo test code 91635), since false-negative results can occur in up to 10-20% of B-cell malignancies with testing for IGH only. The highest rates of non-detectable IGH clonal rearrangements are in IGVH-mutated B-cell neoplasms such as follicular lymphoma and plasma cell neoplasms and in B-lymphoblastic leukemia/lymphoma due to absent or incomplete B-cell receptor rearrangements.

Collect whole blood or bone marrow in EDTA (lavender-top) tube and
ship refrigerated or room temperature. Stability of whole blood and
bone marrow samples at room and refrigerated temperatures is 1 week.

Paraffin blocks are to be shipped at room temperature. Stability for
paraffin blocks is indefinite.

For tissue samples, fresh frozen tissue is preferred and to be shipped
frozen. Frozen tissue is stable for approximately 1 year at -70 C.

Tissues in formalin fixative or RPMI are to be shipped at room
temperature or refrigerated.

Needle washings in alcohol based fixative (eg. CytoLyt) are
acceptable. Please include pathology report for all fresh FNA, frozen
tissue and FFPE cases (partial/preliminary reports OK).
Setup Schedule
Monday, Wednesday

Reported (Analytical Time)
5 days

CPT Codes
81261,G0452+26

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature. Methodology: Polymerase Chain Reaction, Fragment Analysis **Please note: Test includes pathologist interpretation**






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