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90474: PAX8/PPAR[gamma] Translocation, Thyroid Cancer Print View
Specimen Source:      
Block/Specimen ID:      
PAX8/PPAR gamma RT-PCR  Not detected   

PRIMARY
1 Slides (Unstained) 4 (2) mL   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  
ALTERNATE
  Tissue Paraffin Block   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  

PAX8/PPARG translocation is associated with 25-50% of follicular thyroid carcinoma but has also been reported at low frequency in follicular adenomas. Correlation with morphologic and clinical findings is thus required. This assay detects elevated levels of PPARG transcripts, compared to a control gene, associated with PAX8/PPARG translocations by an RNA-based real-time quantitative reverse transcription PCR-based method. The lower limit of sensitivity is approximately 2.5% mutation-bearing cells in a mixed sample, but can vary due to RNA preservation and differing PPARG expression levels in any given neoplasm.

Needle washings in alcohol based fixative (e.g. cytolyt), 4 slides,
or Formalin fixed, paraffin embedded tissue block FNA or FFPE
specimens are acceptable for the assay. All specimens must be
accompanied with Pathology report. Specimens will be examined by a
pathologist for confirmation and microdissection if warranted. A
minimum of 4 FNA slides should be submitted and three should be
without coverslips. Coverslipped slides will delay reporting of
results.


Reject Criteria: Baked slides

Frozen: Do Not Freeze


Transport Temperature: Ship room temperature
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
5 days

CPT Code
81401

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.






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