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90477: BRAF Mutation Analysis, Papillary Thyroid Cancer Print View
Specimen Source      
Block/Specimen ID      
BRAF Mutation RT-PCR  Not detected   

PRIMARY
1 Slides (Unstained) 4 (2) mL   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE
  Tissue Paraffin Block   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
  Needle washings   Room Temperature - 12 Month(s)/Refrigerated - 12 Month(s)  

BRAF V600E mutations are found in 40-50% of papillary thyroid carcinoma (PTC), and much less commonly in anaplastic thyroid carcinoma or poorly differentiated carcinomas involving the thyroid. Correlation with the morphologic and clinical findings is thus required. Cases of PTC with BRAF V600E mutation may be associated with more aggressive tumor characteristics and higher rates of recurrence and treatment failure. The assay tests for codons 600 and 601 BRAF mutations using a DNA-based mutation-specific PCR method, with an approximate sensitivity of 0.1% mutation-bearing cells in a mixed sample. BRAF mutations outside of these codons will not be detected.

Needle washings in alcohol based fixative (e.g. cytolyt), 4 slides,
or Formalin fixed, paraffin embedded tissue block FNA or FFPE
specimens are acceptable for the asssay. All specimens must be
accompanied with Pathology report. Specimens will be examined by a
pathologist for confirmation and microdissection if warranted. A
minimum of 4 FNA slides should be submitted and three should be
without coverslips. Coverslipped slides will delay reporting of
results.
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Reject Criteria: Sample received frozen
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Transport Temperature: Room temperature
Setup Schedule
Tuesday, Saturday

Reported (Analytical Time)
5 days

CPT Code
81210

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.






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