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90649: Cardio IQ® ApoE Genotype Print View
ApoE Genotype      
Comments      
Guidance Statements      
Reviewer      
General Guidance      
Method      
Limitations      

PRIMARY
1 Whole Blood EDTA 4 (2) mL   Frozen - 30 Day(s)/Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)  
ALTERNATE
  Buccal Swab   Room Temperature - 8 Day(s)/Frozen - 30 Day(s)  

Apolipoprotein E is present on chylomicrons, VLDLs, and HDLs and functions as a ligand for lipoprotein receptors. The apoE gene has three common alleles (E2, E3, E4) that code for three isoforms of the apoE protein (E2, E3, E4). The alleles are inherited in a co-dominant manner resulting in six genotypes (e2/e2, e2/e3, e2/e4, e3/e3, e3/e4, e4/e4). Clinical Implications: Individuals who are e2/e2 are prone to develop Type III hyperlipidemia. The E4 allele is associated with increased plasma cholesterol levels and subsequent increased risk for coronary heart disease. ApoE genotype can play a significant role in predicting patient responsiveness to cardiac-related enviromental factors, stain therapy, and dietary therapy. This test is for cardiovascular risk assessment only. Counseling and informed consent are recommended for genetic testing.

Multiple (up to 8) cardiovascular-related genetic tests can be
performed on a single specimen. A second lavender-top (EDTA) tube
is required if non-genetic tests are stimultaneously ordered that
require a lavender-top (EDTA) tube.
For whole blood samples, follow normal phlebotomy procedures.

Buccal Swab collection must use either:

Buccal Swab DNA Collection Kit
Celera Diagnostics, Alameda, CA
Catalog #169045

OR

Buccal Swab Collection Kit
DNA Genotek, Ottawa, ON
Catalog #OC-100
For Buccal Swabs, follow manufacturer's collection instructions.
Setup Schedule
Monday, Wednesday-Saturday

Reported (Analytical Time)
Next day

CPT Code
81401

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Whole Blood: Refrigerated (cold packs) Buccal Swab: Room Temperature Reject Criteria: Incorrect Buccal collection kit Methodology: Real-Time Polymerase Chain Reaction (PCR)






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