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90665: FISH, Myeloproliferative Neoplasms (Eosinophilia) Print View
FISH,MPN (Eosinophilia) FISH     
Specimen Type/Source/Volume:      
Prior Therapy/Transplant:      
Referring Physician:      
Referring Physician Phone:      
Client/Phone #:      
Clinical Indication:      
Client Accession #:      
Patient ID:      

PRIMARY
1 Bone Marrow Heparinized 3 (1) mL   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
ALTERNATE
  Whole Blood Heparin 5 (3) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Whole Blood Heparin Tan 5 (3) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Tissue Paraffin Block   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
  Bone Marrow Hep lead-free   Room Temperature - 72 Hour(s)/Refrigerated - 72 Hour(s)  
  Tissue (Tumor Specimen)   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  Bone Marrow Hep(Royal Bl)   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
  WB NaHep Trace Metal   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  

This FISH panel includes probes that target the PDGFRA (4q12), PDGFRB (5q33.1) and FGFR1 (8p11-12) loci. The probes included in this panel are constructed using the breakapart strategy (fusion signal indicates an intact locus). This allows detection of rearrangements of PDGFRA, PDGFRB, and FGFR1 that result from translocations involving various chromosome regions (usually tyrosine kinase coding genes). Fusion of these receptors with a tyrosine kinase coding gene leads to kinase activation. Rearrangements of PDGFRA, PDGFRB, and FGFR1 are found in a rare group of stem cell myeloid and lymphoid neoplasms that have in common the presence of eosinophilia and the involvement of genes that code for a tyrosine kinase. As such, detection of these rearrangements will help to properly diagnose and follow up these patients. Furthermore, patients with activated tyrosine kinases are good candidates for tyrosine kinase inhibitors.

1-3 mL bone marrow in transport medium or in a sodium heparin
tube (green top, dark/royal blue top, tan top).

Acceptable samples: 3-5 mL whole blood in a sodium heparin tube
(green top, dark/royal blue top, tan top); Formalin fixed
paraffin embedded tumor tissue or 5 mm x 5 mm fresh tumor biopsy
in transport medium.

Clinical history/reason for referral is required with test order.
Prior therapy and transplant history should be provided with test
order.

SPECIMEN VIABILITY DECREASES DURING TRANSIT. SEND SPECIMEN TO
TESTING LAB FOR VIABILITY DETERMINATION. DO NOT REJECT.


Transport Temperature: Ship room temperature
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
5 days

CPT Codes
88271x7,88275x3

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.






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