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90668: Cardio IQ® CYP2C19 Genotype Print View
CYP2C19 Genotype      
Comments      
Guidance Statements      
Reviewer      
General Guidance      
Method      
Limitations      

PRIMARY
1 Whole Blood EDTA 4 (2) mL   Frozen - 30 Day(s)/Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
ALTERNATE
  Buccal Swab   Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)/Frozen - 30 Day(s)  

Multiple variants in the CYP2C19 gene have been described that alter the function of the CYP2C19 enzyme. CYP2C19 genotyping may be an affordable strategy to identify patients that may be at a higher risk for atherothrombotic events. Research indicates that Poor, Intermediate, and Ultra-rapid metabolizers taking Plavix may benefit from alternative dosing strategies or an anti-platelet agent other than Plavix. The clinical impact of the CYP2C19 genotype on the metabolism of specific drugs will vary based on non-genetic factors, such as hepatic and renal status, other medications used (including over-the-counter medications, herbals, and other supplements), alcohol or illegal drug use, race, age, weight, diet, and diseases present in an individual patient. Detection of CYP2C19 genetic variants does not replace the need for assessment of antiplatelet effectiveness and clinical monitoring. Counseling and informed consent are recommended for genetic testing.

Multiple (up to 8) cardiovascular-related genetic tests can be
performed on a single specimen. A second lavender-top (EDTA) tube
is required if non-genetic tests are stimultaneously ordered that
require a lavender-top (EDTA) tube.
For whole blood samples, follow normal phlebotomy procedures.

Buccal Swab collection must use either:

Buccal Swab DNA Collection Kit
Celera Diagnostics, Alameda, CA
Catalog #169045

OR

Buccal Swab Collection Kit
DNA Genotek, Ottawa, ON
Catalog #OC-100
For Buccal Swabs, follow manufacturer's collection instructions.
Setup Schedule
Monday, Wednesday-Saturday

Reported (Analytical Time)
Next day

CPT Code
81225

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Whole Blood: Refrigerated (cold packs) Buccal Swab: Room Temperature Reject Criteria: Incorrect Buccal collection kit Methodology: Real-Time Polymerase Chain Reaction (PCR); Allele specific primer extension






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