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90956: Melanoma, BRAF V600 Mutation, Cobas® Print View
Specimen Source:      
Block/Specimen ID:      
BRAF V600 Mutation   Not detected   

PRIMARY
1 Tissue Paraffin Block 1 (1) g   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE

This FDA-cleared real-time PCR assay on the cobas 4800 platform assesses for mutations at codon 600 of BRAF, particularly V600E, which are present in 40-60% of melanomas. Melanomas with codon 600 BRAF mutations are associated with response to the BRAF-directed kinase inhibitor vemurafenib (ZELBORAF(R)). Tumor DNA is extracted from fixed tumor tissue and subjected to real-time PCR, with approximate sensitivity of 5% mutation-bearing cells in a mixed sample. Other codon 600 BRAF mutations, beside the most common V600E (c.1799T>A) may not be detected by this method.

Formalin fixed paraffin embedded tissue: Formalin fixed paraffin
embedded tissue block. Do not freeze.
Freezing is not recommended for FFPE.
Please contact the Oncology Center at 1(800)642-4657 X 2906, prior
to submission of slides for detailed instructions.
Setup Schedule
Sunday, Tuesday, Friday

Reported (Analytical Time)
6-8 days

CPT Code
81210

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
METHODOLOGY: Real-Time PCR (Cobas) Transport Temperature: Room temperature / Do not thaw Specimen Stability Frozen: Do not Freeze; -70 Degrees: Do Not Freeze






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