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91028: Lung Cancer (NSCLC), Alk 2p23 Rearrangement, FISH Print View
Lung Ca (NSCLC),ALK,FISH      
Specimen Type/Source/Vol:      
Clinical Indication:      
Referring Physician:      
Referring Physician Phone:      
Client/Phone #:      
Client Accession #:      
Patient ID:      

PRIMARY
1 Slides-Formalin Fxd Paraf   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE
  Slides Unstained charged   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  

Non-small cell lung cancer is the leading cause of cancer death worldwide. Tyrosine kinase inhibitors have been demonstrated to reduce lung cancer cell proliferation. The therapeutic efficacy of inhibiting ALK in tumors that were selected by ALK positivity using FISH has been demonstrated in an early-phase clinical trial of a small molecular inhibitor of the ALK tyrosine kinase. The Vysis ALK Break Apart FISH probe kit is a qualitative test to detect rearrangements involving the ALK gene in formalin-fixed paraffin embedded non-small cell lung cancer tissue specimens to aid in identifying those patients eligible for treatment with XALKOR (crizotinib).

Lung tissue biopsy, formalin fixed paraffin-embedded block or
charged/+slides from formalin fixed paraffin embedded tissue.
Specimen MUST be fixed in 10% neutral buffered formalin. Fixation
between 6 and 48 hours is recommended. Pathology report must
accompany paraffin block or slides.

Information required in this report include: Physician
identification, specimen identifiers (case and block number),
specimen site and type, tissue processing used (routine or microwave),
type of fixative, time and duration of fixation, pathologic diagnosis.
Ship at room temperature. Do not freeze.
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
4 days

CPT Codes
88274,88271x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.






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