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91065: BCR-ABL1 Gene Rearrangement, Quantitative PCR Print View
Prior Result:      
Specimen Source:      
BCR-ABL1/ABL1 % QN R-T PCR     
BCR-ABL1/ABL1 % (IS) QN R-T PCR     
Interpretation      

PRIMARY
1 Whole Blood EDTA 6 (4) mL   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  
ALTERNATE
  Bone Marrow   Refrigerated - 72 Hour(s)/Room Temperature - 72 Hour(s)  

This reverse-transcription PCR-based assay detects the BCR-ABL1 transcript produced by the t(9;22) chromosomal translocation associated with chronic myelogenous leukemia (CML) and a subset of lymphoblastic leukemias. For the P190 transcript associated with the minor t(9;22) breakpoint in lymphoblastic leukemia, BCR-ABL1 levels are expressed as a percent ratio of BCR-ABL1 to the normalizing ABL1 transcript. For the P210 transcript associated with CML, quantitation is further adjusted to the international scale (IS) to allow comparison with other IS-compliant BCRABL1 assays. Optimal therapy in CML is associated with transcript levels be low the major molecular response (MMR) milestone indicated by a BCR-ABL1/ABL1 % (IS) below 0.1.

Collect 6 mL of whole blood or 3 mL bone marrow in an EDTA
(lavender-top) tube. Whole blood or bone marrow is shipped at room
temperature or refrigerated. Do not freeze whole blood or bone marrow.
After collection of the sample, draw date and time, as well as sample
type, must be written on the tube and included as requested
information. Ship sample immediately due to short stability of 72
hours. If the stability of the sample cannot be determined, delay in
result or cancellation of test may occur. Clotted specimens are
unacceptable. Do not reject.
Setup Schedule
Monday-Saturday

Reported (Analytical Time)
3 days

CPT Code
81206

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
* If P190 transcript expression was previously documented, only P190 BCR-ABL1 will be added (CPT codes: 81207). * If P210 transcript expression was previously documented, only P210 BCR-ABL1 will be added (CPT codes: 81206). * If no prior positive is documented P190 BCR-ABL1 and P210 BCR-ABL1 will be added (CPT codes: 81206, 81207).






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