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91283: FISH, MET Amplification Print View
FISH, MET Amplification FISH     
Specimen Type/Source/Vol:      
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PRIMARY
1 Tissue Paraffin Block   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  
ALTERNATE
  Tissue in culture media   Room Temperature - 48 Hour(s)/Refrigerated - 48 Hour(s)  
  Slides-Formalin Fxd Paraf   Refrigerated - 12 Month(s)/Room Temperature - 12 Month(s)  

The proto-oncogene MET (c-Met) product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. Over-expression of MET has been observed in variety of neoplasms such as kidney, lung, head and neck, ovary, breast, thyroid, brain, stomach, pancreas and colon. MET gene amplification, detected by FISH, has been associated with an unfavorable prognosis in non-small cell lung cancer (NSCLC) and resistance to EGFR inhibitors.

Acceptable sample: For MET determination in solid tumors, only
biopsies with histologically proven tumor involvement should be
tested.
Samples that can be tested include tumor biopsy in tissue culture
media, formalin fixed paraffin-embedded block or a minimum of 4
charged/+slides from formalin fixed paraffin embedded tissue. Specimen
MUST be fixed in 10% neutral buffered formalin. Fixation between 6 and
48 hours is recommended. Pathology report must accompany paraffin
block or slides.
SPECIMEN VIABILITY DECREASES DURING TRANSIT. SEND SPECIMEN TO TESTING
LAB FOR VIABILITY DETERMINATION. DO NOT REJECT.
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
5 days

CPT Codes
88275,88271x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Whole blood and bone marrow are unacceptable.






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