The Th/To is a component of the 7-2/MRP RNP. Most of the 7-2/MRP RNP is found in the GC region of the nucleolus and <1% of this snoRNP appears located in mitochondria. The Th/To antibodies are present in 10-19% of patients with limited SSc, in 11% of patients with diffuse cutaneous SSc, and in 3% of patients with primary Raynaud's disease. Anti-Th/To antibody has been shown to be highly specific for patients with SSc. The anti-Th/To antibody detection is an in-house bioassay performed at RDL for qualitative determination of Th/To antibody in serum by immunoprecipitation. The Th/To antibody assay will be labeled as an "Analytic Specific Reagent (ASR)".
Reported (Analytical Time)
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