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91446: T-cell Receptor (TCR) Beta Gene Rearrangement, PCR Print View
Clinical Indication:      
Specimen Source:      
Block/Specimen ID:      
TCRB Result      
Pathologist Interpretation      

PRIMARY
1 Whole Blood EDTA 5 (3) mL   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE
  Tissue Paraffin Block   Room Temperature - 12 Month(s)  
  Bone Marrow EDTA   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Needle washings   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Slides (12-Unstained)   Room Temperature - 12 Month(s)  
  Tissue   Frozen - 12 Month(s)  

This assay which interrogates the T-cell receptor beta locus (TCRB) by a PCR method based on the BIOMED-2 consenus, is useful for establishing clonality of T-cell lymphoid neoplasms and identification of minimal residual disease or early recurrence in patients with a previous diagnosis of a T-cell neoplasm. It can be used in association with T-cell receptor (TCR) gamma PCR assay (Test code 90509), since false-negative results can occur in up to 5-10% of T-cell malignancies with TCRB PCR alone.

Collect whole blood or bone marrow in an EDTA (lavender-top) tube and
ship refrigerated or room temperature. Stability of whole blood and
bone marrow samples at room and refrigerated temperatures is 1 week.

Paraffin blocks are to be shipped at room temperature. Stability for
paraffin blocks is indefinite.

For tissue samples, fresh frozen tissue is preferred and to be shipped
frozen. Frozen tissue is stable for approximately 1 year at -70 C.

Tissues in formalin fixative or RPMI are to be shipped at room
temperature or refrigerated.

Needle washings in alcohol based fixative (eg. CytoLyt) are
acceptable. Please include pathology report for all fresh FNA, frozen
tissue and FFPE cases (partial/preliminary reports OK).
Setup Schedule
Tuesday, Thursday, Saturday

Reported (Analytical Time)
3 days

CPT Codes
81340,G0452+26

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature Methodology: Polymerase Chain Reaction, Fragment Analysis **Please note: Test includes pathologist interpretation**






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