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91617: Pain Management, CYP450 3A4 Genotype, Qualitative Print View
3A4 Genotype      
Interpretation      

PRIMARY
1 Whole Blood EDTA 4 (2) mL   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
ALTERNATE
  Whole Blood ACD Sol B 4 (2) mL   Room Temperature - 8 Day(s)/Refrigerated - 8 Day(s)  
  Saliva   Room Temperature - 14 Day(s)/Refrigerated - 14 Day(s)  
  Swab - Buccal   Refrigerated - 14 Day(s)  
  Whole Blood ACD Sol A 4 (2) mL   Refrigerated - 8 Day(s)/Room Temperature - 8 Day(s)  

CYP3A4 and CYP3A5 are liver enzymes that are responsible for metabolizing approximately 50% of small molecule drugs, and their induction often causes unwanted drug-drug interactions and potential toxicities. Variants of CYP3A4/3A5 are associated with significant phenotypic variations that alter the rate of drug metabolism and may cause iincreased or decreased drug efficacy or adverse drug reactions. Detecting genetic predisposition to altered CYP3A4/3A5 metabolism may help to avoid drug toxicity and can assist the physician with optimizing therapeutic strategies for maximum efficacy and minimal adverse effects.

Whole Blood: Normal phlebotomy procedure; specimen stability is
crucial. Store and ship ambient immediately. Do not freeze.

Saliva: Use only DNA Genotek Oragene-Dx(OGD-510)kit. Follow
instructions. Store and ship ambient or refrigerated. Do not freeze.

Buccal swab: Use only Celera/Copan DNA collection kit (Celera part
# 5002737). Store and ship ambient only. Do not refrigerate or
freeze.
Setup Schedule
Wednesday

Reported (Analytical Time)
9-16 days

CPT Code
81401

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Rejection Criteria: Incorrect collectin device. Liquid has leaked from container. No liquid present. Blood sample received frozen. Buccal swab received refrigerated or frozen. Methodology: Single Nucleotide Primer Extension






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