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91635: B-cell Clonality Panel (IGH, IGK), PCR Print View
Clinical Indication:      
Specimen Source:      
Block/Specimen ID:      
IGH Result      
IGK Result      
Pathologist Interpretation      

PRIMARY
1 Whole Blood EDTA 5 (3) mL   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)  
ALTERNATE
  Tissue Paraffin Block   Room Temperature - 12 Month(s)  
  Bone Marrow EDTA   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Needle washings   Room Temperature - 7 Day(s)/Refrigerated - 7 Day(s)  
  Slides (12-Unstained)   Room Temperature - 12 Month(s)  
  Tissue   Frozen - 12 Month(s)  

This assay, which interrogates the immunoglobulin kappa light chain gene (IGK) and the immunoglobulin heavy chain (IGH), by a PCR method based on the BIOMED-2 consensus, is useful for establishing clonality of B-cell lymphoid neoplasms. It can be used also for identification of minimal residual disease or early recurrence in patients with a previous diagnosis of a B-cell neoplasm. Testing for both IGH and IGK gene rearrangements is reported to detect up to 99% of B-cell malignancies, compared to 80-90% for IGH and 85-90% for IGK alone.

Collect whole blood or bone marrow in EDTA (lavender-top) tube and
ship refrigerated or room temperature. Stability of whole blood and
bone marrow samples at room and refrigerated temperatures is 1 week.

Paraffin blocks are to be shipped at room temperature. Stability for
paraffin blocks is indefinite.

For tissue samples, fresh frozen tissue is preferred and to be shipped
frozen. Frozen tissue is stable for approximately 1 year at -70 C.

Tissues in formalin fixative or RPMI are to be shipped at room
temperature or refrigerated.

Needle washings in alcohol based fixative (eg. CytoLyt) are
acceptable. Please include pathology report for all fresh FNA, frozen
tissue and FFPE cases (partial/preliminary reports OK).
Setup Schedule
Monday, Wednesday

Reported (Analytical Time)
5 days

CPT Codes
81261,81264,G0452+26

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature. Methodology: Polymerase Chain Reaction, Fragment Analysis **Please note: Test includes pathologist interpretation**






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