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91771: MYD88, Mutation Analysis Print View
Specimen Source:      
Block/Specimen ID:      
Clinical Indication      
MYD88 L265P Mutation   Not Detected   
Interpretation      

PRIMARY
1 Whole Blood EDTA 5 (2) mL   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
ALTERNATE
  Bone Marrow EDTA   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Whole Blood Heparin 5 (2) mL   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
  Whole Blood ACD Sol B 5 (2) mL   Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  

L265P mutation in the MYD88 gene is found in approximately 90% of Waldenstrom macroglobulinemia and IgM-expressing lymphoplasmacytic lymphoma (LPL). There is a low incidence of L265P MYD88 mutation in other systemic CD5-negative B-cell lymphoproliferative disorders including atypical chronic lymphocytic leukemia, nodal marginal zone lymphoma (MZL), splenic MZL and mucosa-associated lymphoid tissue (MALT)-type MZL. This PCR-based DNA pyrosequencing assay sensitively detects the L265P MYD88 mutation and can be used to help diagnose Waldenstrom macroglobulinemia or IgM-expressing lymphoplasmacytic lymphoma and to help in stratifying or subclassifying patients with IgM monoclonal gammopathy.

Preferred: 5 mL (2 mL minimum) whole blood collected in an EDTA
(lavender-top) tube.

Acceptable: Whole blood collected in a sodium heparin (green-top) or
ACD-B (yellow-top) tube. 2 mL (0.5 mL minimum) bone marrow aspirate
collected in an EDTA (lavender-top) tube. Formalin-fixed, paraffin-
embedded tissue block. Slide: 10 slides tissue submitted in a slide
holder.
Setup Schedule
Sunday-Saturday

Reported (Analytical Time)
5 days

CPT Code
81479

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Methodology: DNA Sequencing Reject Criteria: Received Frozen Transport Temperature: Room temperature






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