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91969: PD-L1 Monocyte Expression, SLE Flare Print View
PD-L1 Monocyte Exp,SLE Flr     % 
Ratio   > 4  Ratio 

PRIMARY
1 Whole Blood Heparin 10 (5) mL   Room Temperature - 30 Hour(s)  
ALTERNATE

PD-L1, (also known as B7-H1/CD274) is B7 family member expressed by hematopoietic and parenchymal cells that regulates self-tolerance in vivo by binding to programmed cell death-1 (PD-1) on T lymphocytes, causing both inhibition of T lymphocyte activation directly and through induction of T regulatory cells. Blockade or absence of the PD-L1:PD-1 interatction results in exacerbation of autoimmune diseases. During disease flares, patients with SLE fails to upregulate PD-L1 expression on circulating antigen presenting cells. In remission, SLE patients expressed PD-L1 at levels equal to or greater than controls.

Fasting preferred to avoid lipemia.
***CLIENTS-CONTACT THE LAB PRIOR TO ORDERING FOR SPECIAL LOGISTICS
ARRANGEMENTS***
***PSC-FOLLOW SHORT STABILITY SOP***
Test available by prior arrangement only. Special sample collection
and transportation arrangements must be made prior to ordering the
test. Contact your local Customer Service Department and request to
speak to someone in Referral Testing Department for specific
instructions.
10 mL (minimunm of 5 mL) whole blood collected in sodium heparin-green
-top. Aseptically collect whole blood into specimen collection tube
containing sodium heparin.
Whole blood must be transported at room temperature. Samples should be
received within 30 hours from collection. An appropriate time should
be selected for expeditious transport. Maintain and transport blood at
room temperature. Avoid temperatures < 15 degree (C) and > 37 degree
(C). In hot weather, it may be necessary to pack the specimen in a
container with insulating material around it and place this container
inside another that contains a cold pack (ice pack) and absorbent
material. This method will help retain the specimen at ambient
temperature.
For longitudinal studies, draw samples at the same time of day to
minimize diurnal variation.
*Samples received > 30 hours after collection will be rejected.*
Setup Schedule
Tuesday-Friday

Reported (Analytical Time)
Next day

CPT Codes
88184,88185x3

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
**This test is not available for New York patient testing.** Reject Criteria: Hemolysis, received refrigerated, received frozen, visible clots, sample > 30 hours Transport Temperature: Room temperature Methodology: Peripheral Blood






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