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91998: Tamoxifen and Metabolites, LC-MS/MS Print View
Menopausal Status      
Interpretation      
Endoxifen LC-MS/MS  6.01 - 43.19  ng/mL 
Tamoxifen LC-MS/MS  12.54 - 233.07  ng/mL 
N-Desmethyl Tamoxifen LC-MS/MS  2.59 - 373.96  ng/mL 
4-Hydroxy Tamoxifen LC-MS/MS  0.24 - 5.05  ng/mL 
N-Desmethyl-4'-Hydrox Tam LC/MS/MS  1.17 - 19.95  ng/mL 
4'-Hydroxy Tamoxifen LC-MS/MS  0.4 - 6.33  ng/mL 
Always Comment      

PRIMARY
1 Serum Red Top 0.5 (0.3) mL   Frozen - 12 Month(s)/Refrigerated - 7 Day(s)/Room Temperature - 7 Day(s)  
ALTERNATE

Tamoxifen is a prodrug and undergoes biotransformation into a series of metabolites. N-desmethyl tamoxifen is the most abundant metabolite. 4-Hydroxy tamoxifen and N-desmethyl-4-hydroxy tamoxifen (endoxifen) are the most potent metabolites. Studies have shown that genetic variations in the CYP2D6 enzymes influence endoxifen levels. Due to this variability, monitoring endoxifen levels and phase one metabolite rather than CYP2D6 genotype testing is suggested to be a better approach for monitoring tamoxifen therapy.

Collect blood in a red-top vacutainer tube. Allow blood to clot
(10-15 minutes) at room temperature before centrifugation.
Separate serum from cells into a standard 13x100 mm tube.

Transport Temperature: Room temperature
Setup Schedule
Wednesday, Friday

Reported (Analytical Time)
Next day

CPT Code
83789

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Plasma; serum separator tube; hemolysis






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