C. difficile causes 50-75% of antibiotic associated colitis and than 90% of antibiotic associated pseudomembranous colitis. Pathogenic C. difficile produce two potent toxins, toxin A and toxin B, that cause diarrhea and colitis.
Toxin is heat labile. Freeze as soon as possible. Submit frozen
stool in sterile screw-cap container or use anaerobic transport.
Reported (Analytical Time)
The CPT codes provided are based on AMA guidelines and are for informational purposes only.
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Please direct any questions regarding coding to the payer being billed.
Reject Criteria: Received room temperature; received in Cary-Blair transport; specimen other than liquid or semi-formed stool; stool in preservative or mixed with urine; specimen in wrong transport container. Specimen Volume Note: 5 g or 5mL (2g or 2mL minimum) unpreserved stool collected in a sterile screw cap container Specimen Stability: Room temperature: Unacceptable; Refrigerated: 48 hours; Frozen -20: Not established; Frozen -70: 7 days Transport Temperature: Frozen Methodology: Conventional Culture If Clostridium difficile Culture is "Isolated" then the Clostridium difficile Toxin B, Qualitative Real-time PCR, Isolate is performed at an additional charge (CPT code(s): 87493)