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92813: ANA Screen,IFA, with Reflex to Titer and Pattern/Rheumatoid Arthritis Panel 2 Print View
ANA Screen, IFA      
Rheumatoid Factor IMMUNOTURB    IU/mL 
CCP Antibody (IgG) ELISA    Units 
Interpretation      
14-3-3 eta Protein ELISA    ng/mL 

PRIMARY
1 Serum 3.4 (1.7) mL   Room Temperature - 4 Day(s)/Refrigerated - 7 Day(s)/Frozen - 21 Day(s)  
ALTERNATE

Anti-nuclear antibody (ANA) tests are a general indicator of autoimmune disease. Many people with RA have positive ANA tests. ANA tests. Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neuropsychiatric SLE. Early diagnosis of rheumatoid arthritis (RA), i.e, diagnosis before significant joint erosion occurs, is difficult. Psoriatic arthritis can also be difficult to diagnose clinically early in the disease process, and there are no specific biomarkers. The 14-3-3eta protein is anemerging biomarker for RA and erosive psoriatic arthritis diagnosis. It may play a biologic role in the joint erosive process. Blood levels may be elevated in patients with RA, but not in other diseases including psoriasis, osteoporosis, gout, ulcerative colitis, type 1 diabetes, systemic lupus erythematosus, Crohn disease, systemic lupus erythematosus, Crohn disease, primary Sjogren syndrome, scleroderma, and multiple sclerosis. The 14-3-3eta protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptid e (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA. It may also help differentiate those psoriasis patients with psoriatic erosive arthritis joint damage from those without joint damage.

Allow blood to clot (10-15 minutes) at room temperature.
Centrifuge and separate from cells. Ship refrigerated.
Setup Schedule
Wednesday, Saturday

Reported (Analytical Time)
3 days

CPT Codes
86038,86431,86200,83520

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature
Reject Criteria: Gross hemolysis; grossly lipemic; microbial contamination may interfere; plasma
Methodology: Immunofluorescence Assay (IFA); Immunoturbidometry; Enzyme Linked Immunosorbent Immunoassay
Reflex Criteria: If ANA Screen, IFA is positive, then ANA, Titer & Pattern will be performed at an additional charge (CPT code(s) 86039).






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