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92977: Anti-Annexin V IgG and IgM Print View
Anti-Annexin IgG     U/mL 
Anti-Annexin IgM     U/mL 

PRIMARY
1 Serum 0.5 (0.2) mL   Room Temperature - 6 Hour(s)/Refrigerated - 5 Day(s)/Frozen - 6 Month(s)  
ALTERNATE
  Plasma EDTA 0.5 (0.2) mL   Room Temperature - 6 Hour(s)/Refrigerated - 5 Day(s)/Frozen - 6 Month(s)  

Annexin V is a glycoprotein (Mol Wt: 36Kd) that has the ability to bind to negatively charged phospholipids serine with high affinity in a calcium dependent manner. Based on its strong phospholipid activity, it inhibits in vitro the thrombinase complex and the tenase complex, resulting in potent anticoagulant activity. The occurrence of autoantibodies to annexin V has been described in several pathological disorders. It is concluded that extracellular annexin V provides an antigenic stimulus for autoantibody production. The elevated levels of autoantibodies to annexin V (especially IgG isotype) have been demonstrated in serum samples of patients with systemic lupus erythomatosis (SLE), rheumatoid arthritis, recurrent fetal loss (miscarriage) and pre-eclampsia. A number of studies suggest that the displacement on annexin V shield from the syncytiotrophoblast surface in placenta by anti-annexin V antibodies is causative in the generation of thrombogenic environment and consequently fetal loss. An increased prevalence of elevated anti-annexin V IgM and to a lesser extent anti-annexin V IgG was seen in recurrent spontaneous miscarriage patients.
Setup Schedule
Tuesday

Reported (Analytical Time)
Next day

CPT Code
83516x2

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Reject Criteria: Gross hemolysis; received room temperature Transport Temperature: Frozen Methodology: Enzyme Linked Immunosorbent Immunoassay Assay Category: Research Use Only






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