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93748: Early Sjogren's Syndrome Profile Print View
Salivary Protein 1 IgG Abs* ELISA  < 20.0  EU/ml 
Salivary Protein 1 IgA Abs* ELISA  < 20.0  EU/ml 
Salivary Protein 1 IgM Abs* ELISA  < 20.0  EU/ml 
Carbonic Anhydrase VI IgG Abs* ELISA  < 20.0  EU/ml 
Carbonic Anhydrase VI IgA Abs* ELISA  < 20.0  EU/ml 
Carbonic Anhydrase VI IgM Abs* ELISA  < 20.0  EU/ml 
Parotid Spec. Protein IgG Abs* ELISA  < 20.0  EU/ml 
Parotid Spec. Protein IgA Abs* ELISA  < 20.0  EU/ml 
Parotid Spec. Protein IgM Abs* ELISA  < 20.0  EU/ml 
Serology Comments      

PRIMARY
1 Serum 2 (0.5) mL   Frozen - 12 Month(s)/Refrigerated - 5 Day(s)/Room Temperature - 5 Day(s)  
ALTERNATE

Sjogren's syndrome (SS) is a systemic autoimmune disease in which loss of salivary gland and lachrymal gland function is associated with hypergammaglobulinemia, autoantibody production, mild kidney and lung disease and eventually lymphoma. SS involves dry eyes and dry mouth without systemic features that may be either primary or secondary to another autoimmune disease, such as SLE. Patients with SS and picked up at a late stage in their disease, after the salivary glands and lachrymal glands are already destroyed, because they are asymptomatic until that time. At this point, only symptomatic treatment can be offered for abnormal lachrymal and salivary gland function. The diagnosis for SS is currently at a crossroad with the American College of Rheumatology providing which requires characteristic autoantibodies (SS-A/SS-B) or minor salivary gland biopsy. Since lip biopsies are not frequently performed in clinical practice, there is increased emphasis placed on autoantibodies in diagnosis. The current Ro and La antibodies can delay the diagnosis by over 6 years. Recently novel antibodies identified to salivary gland protein 1 (SP-1), carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP) using western blot methodology. Further studies have 34 shown that the isotype differentiation of the markers adds to the sensitivity of diagnosis of SS. These autoantibodies occurred earlier in the course of the disease than antibodies to Ro or La. In addition antibodies to SP-1, CA-6 and PSP were found in patients meeting the criteria for SS who lacked antibodies to Ro or La. Furthermore, in patients with idiopathic xerostomia and xerophthalmia for less than 2 years, 76% had antibodies to SP-1 and/or CA6 while only 31% had antibodies to Ro or La. Antibodies to different isotypes (IgG, IgM & IgA of SP-1, CA6 and PSP are useful markers for identifying patients with SS at early stages of the disease or those that lack

Specimen Requirements: Specimen need not be refrigerated or frozen.
Collect 4-10 ml of blood in a red top or serum seperator tube. If
seperation facilities are not available, the blood can be sent in the
tube used for collection.
Setup Schedule
Monday

Reported (Analytical Time)
14 days

CPT Code
83520x9

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
**Schedule Turnaround Time: Assay performed once every two weeks. Report availability is two weeks from the time of specimen receipt. Transport Temperature: Room Temperature Methodology: Enzyme Linked Immunosorbent Immunoassay (ELISA) Reject Criteria: Gross Hemolysis; Grossly lipemic; Grossly icteric






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