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93876: Paraneoplastic Antibody Evaluation w/Reflex to Titer and Line Blot, Basic Print View
Tissue IFA Observation(s)      
ANNA1 (Hu) Ab, IFA      
ANNA2 (Ri) AB, IFA      
ANNA3 Ab, IFA      
PCA1 (Yo) Ab, IFA      
PCA2 AB, IFA      
PCA-Tr (DNER) Ab, IFA      
AGNA/SOX1 Ab, IFA      
Amphiphysin Ab, IFA      
CRMP5/CV2 Ab, IFA      
Striated Muscle Ab      
VGCC Type P/Q Ab     pmol/L 
VGKC Ab     pmol/L 
AChR Ganglionic (Alpha3) Ab     pmol/L 
VGCC Type N Ab     pmol/L 
Acetylcholine Rec Bind Ab     nmol/L 

PRIMARY
1 Serum 6 (3.5) mL   Room Temperature - 48 Hour(s)/Refrigerated - 48 Hour(s)/Frozen - 21 Day(s)  
ALTERNATE

Detection of antineuronal autoantibodies aids the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions. Identification of specific antineuronal autoantibodies may direct evaluation for underlying often occult malignancy. Characterization of autoantibody specificity may allow syndromic classification and assist in diagnosis and management. Antineuronal antibodies are detected and characterized based on indirect immunofluorescence staining pattern on multiple neuronal, non-neuronal tissues, and transformed substrate cells, and radioimmunoassays, and western blot analysis.
Setup Schedule
Tuesday-Saturday

Reported (Analytical Time)
7 days

CPT Codes
86255x10,83519x5

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Absolute Minimum Volume: 2.0 mL
Reflex Criteria: If Paraneoplastic Ab Scrn, IFA, Basic is positive for ANNA3, then ANNA-3 Ab, IFA Titer will be performed at an additional charge. If Paraneoplastic Ab Scrn, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge. If Paraneoplastic Ab Scrn, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge. If Paraneoplastic Ab Scrn, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge. If Paraneoplastic Ab Scrn, IFA, Basic is positive or indeterminate, then Paraneoplastic Ab, WB, Basic will be performed at an additional charge. If Anti-Striated Muscle Ab Screen is positive, then Anti-Striated Muscle Ab Titer will be performed at an additional charge. If AChR Binding Ab is positive (>or =0.50) or Equivocal(0.31-0.49), then Paraneoplastic Ab, WB, Basic and AChR Modulating Ab will both be performed at additional charges.
Methodology:
Immunofluorescence Assay, Radiobinding Assay, Radioimmunoassay
Transport Temperature: Frozen






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