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93932: Hla-b*58:01 Typing Print View
HLA-B*58:01      

PRIMARY
1 Whole Blood EDTA 5 (3) mL   Refrigerated - 10 Day(s)/Room Temperature - 7 Day(s)  
ALTERNATE
  Whole Blood (Citrated) 5 (3) mL   Refrigerated - 10 Day(s)/Room Temperature - 7 Day(s)  
  WB EDTA Trace Metal   Room Temperature - 7 Day(s)/Refrigerated - 10 Day(s)  
  Whole Blood EDTA Pink 5 (3) mL   Refrigerated - 10 Day(s)/Room Temperature - 7 Day(s)  
  Whole Blood ACD 5 (3) mL   Room Temperature - 7 Day(s)/Refrigerated - 10 Day(s)  
  Whole Blood Heparin 5 (3) mL   Refrigerated - 10 Day(s)/Room Temperature - 7 Day(s)  

HLA B*58:01 has been associated with severe cutaneous adverse reactions (SCAR) in response to the drug Allopurinol. The Clinical Pharmacogenomic Implementation Consortium, CPIC, has published an article recommending genotyping prior to getting allopurinol treatment, and recommended that the drug should not be administered to patients with the HLA-B*58:01 allele. Frequency of allele varies with ethnicity: 6% to 7% in Asians, 1% in Caucasians. Similarly, the American College of Rheumatology has published guidelines for the management of gout utilizing allopurinol among other medications. They recommended HLA-B*58:01 testing in high-risk all patients of Han Chinese and Thai descent and Koreans with stage 3 or worse chronic kidney disease.
Setup Schedule
Tuesday, Thursday, Saturday

Reported (Analytical Time)
8 days

CPT Code
81381

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Room temperature

Reject Criteria: Clotted sample

Methodology
Screen: Allele Specific PCR
Confirmation: LABType(R) SSO






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