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93958: 2,3-Dinor-11Beta-Prostaglandin F2 Alpha, Urine Print View
2,3-dinor 11B-Prostagland U LC/MS/MS  < 5205  pg/mg Cr 

PRIMARY
1 Urine 24 hour 4 (3) mL   Refrigerated - 14 Day(s)/Room Temperature - 8 Hour(s)/Frozen - 30 Day(s)  
ALTERNATE
  Urine   Refrigerated - 14 Day(s)/Frozen - 30 Day(s)/Room Temperature - 8 Hour(s)  

2,3-Dinor-11beta-prostaglandin F2 alpha is the most abundant metabolic product of prostaglandins released by activated mast cells. Systemic mastocytosis (SM) is a disease in which clonally derived mast cells accumulate in peripheral tissues. Degranulation of these mast cells releases large amounts of histamines, prostaglandins, leukotrienes, and tryptase. World Health Organization diagnostic criteria for SM require the presence of elevated mast cell counts on a bone marrow biopsy and 1 of the following minor criteria: abnormal mast cell morphology, KIT Asp816Val mutation, CD25-positive mast cells, or serum tryptase >20 ng/mL. Alternatively, SM diagnosis can be made with the presence of 3 minor criteria in the absence of abnormal bone marrow studies. Measurement of mast-cell mediators in blood or urine is less invasive and is advised for the initial evaluation of suspected cases. Elevated levels of serum tryptase, urinary N-methylhistamine (NMH), 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG), or leukotriene E4 (LTE4) are consistent with the diagnosis of systemic mast cell disease.

Preferred: 24-hour urine collection
Container/Tube: Plastic, 5-mL tube (Supply T465)
1. Collect urine for 24 hours.
2. No preservative preferred.

Acceptable: Random collection
Container/Tube: Plastic, 5-mL tube (Supply T465)
1. Collect a random urine specimen.
2. No preservative preferred.
Setup Schedule
Monday, Thursday

Reported (Analytical Time)
4 days

CPT Code
84150

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Notes
Transport Temperature: Refrigerated Methodology: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)






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